Magic Mushroom rewires the brain to relieve depression

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Magic Mushroom rewires the brain to relieve depression

Magic mushrooms are also called shrooms or mushrooms. They are a type of mushroom that contains the drugs psilocybin or psilocin and these drugs cause hallucinations after consumption. Depression is a medical illness that negatively affects how a person feels, thinks, or acts.

A study just published in Nature Medicine found that people with depression who took two doses of psilocybin, the active ingredient in psychedelic mushrooms, experienced not only an improvement in their symptoms but also what the study authors described as “increased global integration in the brain.”

According to the authors, Psilocybin-induced “dynamic flexibility” helps people with treatment-resistant depression in ways that traditional antidepressants don’t.

The study assessed the subacute impact of psilocybin on brain function in two clinical trials – the first was an open-label trial of orally administered psilocybin and the second trial was a double-blind phase II randomized controlled trial comparing psilocybin therapy with escitalopram.

A part of the study read: “In both trials, the antidepressant response to psilocybin was rapid, sustained and correlated with decreases in fMRI brain network modularity, implying that psilocybin’s antidepressant action may depend on a global increase in brain network integration.”

“One exciting implication of our findings is that we have discovered a fundamental mechanism via which psychedelic therapy works not just for depression – but other mental illnesses, such as anorexia or addiction,” says co-author Carhart-Harris.


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    Heba Kamal Nabih 5 months ago

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