Relationship between the complications of viral hepatitis and oxidative stress

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Relationship between the complications of viral hepatitis and oxidative stress

Viral hepatitis infection could develop several complications including chronic infection, acute or sub-acute hepatic necrosis, cirrhosis, liver failure, and hepatocellular carcinoma. The goal of this study was to estimate the effect of viral hepatitis B infection on some hematological and oxidative stress markers in men patients.

Thirty voluntary men from the El Oued region were divided equally into hepatitis B patients and control groups. Prediction tests of oxidative stress markers were estimated using ROC curve analysis.

Results showed that the leukocytes and platelet lines cells were significantly increased but the erythrocyte line was significantly decreased in the hepatitis group as compared to the control group. In this experimental study, the result showed a significant increase of serum MDA level, SOD and catalase activities, also a significant decrease of serum GSH in the hepatitis group compared to the control group. ROC analysis indicated that all of MDA and GSH levels, SOD and catalase activities were a high specificity and important AUC percentage with high correlation with risk factors of hepatitis B.

Results indicated that hematotoxicity and change in oxidative stress markers were the origins of the severity of hepatitis B infection. In addition, MDA, SOD, GSH and catalase were considered important diagnostic tools for follow-up and predicting complications of hepatitis B.

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